If you are struggling with depression and have not found relief with traditional antidepressants, ketamine therapy may offer a new path forward. At Salt Meadow Psychiatry, we provide Spravato®, an FDA-approved form of ketamine therapy designed for adults with treatment-resistant depression and certain forms of major depressive disorder.
Led by Dr. Daniel Perry, MD, MPH, our practice offers personalized psychiatric care that focuses on long-term emotional wellness, symptom improvement, and evidence-based treatment. Every patient receives a comprehensive evaluation to determine whether Spravato treatment is an appropriate option for their individual needs.

Spravato (esketamine) is a prescription nasal spray derived from ketamine. Unlike traditional antidepressants that primarily target serotonin, Spravato works through glutamate pathways in the brain, helping support neural connections involved in mood regulation and emotional health.
Spravato is FDA-approved for adults with treatment-resistant depression and for certain patients experiencing major depressive disorder with acute suicidal thoughts or behaviors. Treatment is administered in a monitored medical setting and follows established safety protocols designed to support patient comfort and well-being.
Ketamine therapy works differently from many conventional depression treatments. By targeting glutamate receptors, Spravato may help promote neural connectivity and improve communication between areas of the brain involved in mood regulation.
For individuals who have not responded to multiple antidepressants, this unique mechanism may provide meaningful symptom improvement when other treatments have been unsuccessful. Many patients begin noticing positive changes within the first several weeks of treatment.
Patients may choose ketamine therapy for several reasons, including:
Spravato may be appropriate for adults who:
Every patient undergoes a comprehensive psychiatric evaluation before treatment begins. This evaluation helps determine whether Spravato is an appropriate and safe option based on medical history, current symptoms, and treatment goals.
One of the advantages of Spravato treatment is that it is covered by many insurance plans. Because Spravato is FDA-approved, eligible patients may have significantly lower out-of-pocket costs compared to self-pay IV ketamine infusions.
Our team assists with insurance verification and prior authorization whenever possible, helping patients understand potential coverage and treatment costs before beginning care.
Although both Spravato and IV ketamine are used to help individuals with treatment-resistant depression, there are important differences.
Spravato is an FDA-approved nasal spray administered under psychiatrist supervision in a structured medical setting. Treatment follows established clinical protocols and includes observation before and after each session.
IV ketamine is typically administered through infusions and is considered an off-label treatment for depression. Coverage, monitoring, and treatment protocols may vary depending on the provider.
For many patients, Spravato offers a regulated, evidence-based treatment option integrated into ongoing psychiatric care.
Treatment sessions take place in a comfortable clinical environment under medical supervision. Patients self-administer the nasal spray as directed and remain in the office for monitoring following treatment.
Our goal is to provide a safe, supportive experience while ensuring every patient receives the guidance and oversight necessary throughout the treatment process.
Many patients begin noticing symptom improvement within the first several weeks of Spravato treatment, although individual results vary.
Spravato contains esketamine, a form of ketamine that is FDA-approved for certain types of depression.
Many insurance plans cover Spravato treatment for eligible patients. Coverage varies based on individual plans and medical necessity.
Appointments include administration and monitoring time. Most visits last several hours to ensure safety and proper observation.
Adults with treatment-resistant depression or certain forms of major depressive disorder may qualify after a psychiatric evaluation.
At Salt Meadow Psychiatry, ketamine therapy is not treated as a standalone procedure. Instead, it is integrated into a comprehensive psychiatric care plan designed around your unique needs and long-term goals.
Dr. Daniel Perry provides personalized evaluations, ongoing monitoring, medication management, and evidence-based treatment recommendations to help patients achieve meaningful and lasting improvements in their mental health.
Our practice is committed to delivering compassionate, patient-centered care in a professional and supportive environment.
Living with depression can feel overwhelming, especially when previous treatments have not provided the results you hoped for. If you are exploring ketamine therapy in Savannah, GA, Dr. Daniel Perry can help determine whether Spravato treatment may be an appropriate option for your needs.
Schedule a confidential consultation today to discuss your symptoms, treatment history, and goals for recovery.
📞 Call 912-513-2888
📅 Or schedule your consultation online
Salt Meadow Psychiatry proudly provides ketamine therapy and Spravato treatment for patients throughout Savannah, Pooler, Richmond Hill, Wilmington Island, Garden City, Tybee Island, and surrounding Georgia communities. Through personalized psychiatric care and evidence-based treatment, we help adults access advanced depression treatment options close to home.
Disclaimer: This page is for informational purposes only and does not constitute medical advice. Always consult a licensed provider before beginning any treatment.
