At Salt Meadow Psychiatry, we provide specialized treatment for treatment-resistant depression in Savannah, GA. Led by Dr. Daniel Perry, MD, MPH, our practice helps adults who continue to experience depressive symptoms despite trying traditional antidepressant medications.
Living with persistent depression can feel discouraging, especially when multiple treatments have not provided meaningful relief. Our goal is to help patients explore evidence-based treatment options, develop personalized care plans, and regain hope for long-term emotional wellness.
Through comprehensive psychiatric evaluations, medication management, and advanced therapies such as Spravato®, we help patients access modern treatment options designed for complex depression.

Treatment-resistant depression (TRD) is a form of major depressive disorder that does not adequately respond to at least two antidepressant medications taken at appropriate doses and durations.
Individuals with treatment-resistant depression often continue to experience symptoms such as:
Treatment-resistant depression is more common than many people realize and does not mean recovery is impossible. Advances in psychiatric medicine have created new treatment options for individuals who have not responded to conventional approaches.
Effective treatment begins with a thorough understanding of your history and symptoms.
At Salt Meadow Psychiatry, every patient undergoes a comprehensive psychiatric evaluation that may include:
This evaluation helps determine whether treatment-resistant depression is present and identifies the most appropriate next steps for care.
For eligible patients, Spravato® (esketamine) may be recommended as part of a comprehensive treatment plan.
Spravato is an FDA-approved nasal spray specifically indicated for adults with treatment-resistant depression. Unlike traditional antidepressants that primarily affect serotonin pathways, Spravato works through glutamate pathways involved in mood regulation and neural connectivity.
Treatment is administered in a monitored clinical setting under medical supervision and follows established safety protocols.
Many patients who have not found relief through conventional medications explore Spravato as an advanced treatment option when other approaches have been unsuccessful.
You may benefit from an evaluation if you:
Every patient receives an individualized assessment to determine which treatment options may be most appropriate.
Treatment-resistant depression often requires more than a single intervention.
Dr. Perry develops personalized treatment plans that may include:
Our approach focuses on long-term symptom improvement, emotional stability, and overall quality of life.
Patients choose Salt Meadow Psychiatry because we provide thoughtful, individualized care in a supportive and professional environment.
Our practice offers:
We understand that treatment-resistant depression can be frustrating and exhausting. Our goal is to help patients explore evidence-based options while providing guidance and support throughout the treatment process.
Treatment-resistant depression is depression that has not improved adequately after at least two antidepressant treatment trials.
No. Many individuals with treatment-resistant depression experience meaningful improvement through advanced treatment options and personalized psychiatric care.
Treatment options may include medication adjustments, Spravato therapy, psychotherapy, and other evidence-based interventions depending on individual needs.
Eligibility is determined through a comprehensive psychiatric evaluation that reviews your diagnosis, treatment history, and overall health.
Coverage varies by insurance plan and treatment type. Our office can help review available options and discuss potential coverage.
Salt Meadow Psychiatry proudly serves patients throughout Savannah, Pooler, Richmond Hill, Wilmington Island, Garden City, Tybee Island, Skidaway Island, and surrounding Coastal Georgia communities.
We are committed to helping adults access advanced depression treatment options close to home through compassionate, evidence-based psychiatric care.
If depression continues to affect your life despite previous treatment attempts, help is available.
Contact Salt Meadow Psychiatry to schedule a confidential consultation and learn more about treatment options for treatment-resistant depression in Savannah, GA.
📞 Call 912-513-2888
📅 Request an Appointment Online
📍 Savannah, Georgia
